Cotransin ct8
Web,nM)ofIpomoeassinF,Cotransin (CT8), and Probes 3, 5, and 7−15a cell line MDA-MB-231b MCF7 MCF-10A HCT116b,c ipomoeassin F 6.3 36.4 5.3 8 CT8 −d −−243 3 6.3 22.2 9.6 − 5 29.5 187.4 21.7 − 7 7.0 19.8 5.1 − 8 >25,000 >25,000 − 2832 9 >25,000 >25,000 −− 10 8.9 172.2 11.3 − 11 2.8 21.1 2.0 − 12 253.4 172.2 133.8 − 14 98018 ... WebJan 1, 2024 · CT8 is a member of a class of synthetic cyclic depsipeptides known as cotransins that were developed through rational design as simplified analogues of the fungal natural product HUN-7293 [24], [35].HUN-7293 is a complex heptadepsipeptide that was discovered as an inhibitor of vascular cell-associated adhesion molecule expression [36], …
Cotransin ct8
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WebHowever, the complement of the human proteome amenable to cotransin modulation has remained largely unexplored. Using quantitative membrane proteomics, we identify targets of a selective cotransin analog, CT8, in an unbiased manner. We show that CT8 inhibits only 6.5% of the global proteome and 25% of the secreted proteome in JJN-3 cells. WebFeb 4, 2014 · In this study, we have exploited a small-molecule inhibitor of cotranslational integration (cotransin, CT8) to trap and interrogate a …
WebWe begin to explore the myeloma-specific mechanism of CT8-induced apoptosis by showing that the CT8-sensitive ER-resident chaperone p58ipk is an essential protein in multiple myeloma cells. This study furnishes a method for predicting new cotransin-sensitive proteins, thereby allowing for the rapid identification of clinically relevant arenas ... WebSep 23, 2011 · Whilst many Sec61 inhibitors including mycolactone 44,53 , apratoxin A 54 and coibamide A 55 are reported to have wide-ranging effects on ER translocation, others like cotransin (CT8) are more ...
WebNov 7, 2016 · Europe PMC is an archive of life sciences journal literature. WebThe meaning of COTRANSFER is an act, process, or instance of transferring something along with one or more related things; also : cotransduction. How to use cotransfer in a …
WebMar 14, 2024 · Europe PMC is an archive of life sciences journal literature.
WebJan 26, 2015 · The small-molecule cotransin CT8 binds the Sec61 translocon and prevents the signal peptide of the nascent HER3 protein … royalty free botanical imagesWebNov 14, 2024 · HER3 (G11L/S15L), that is fully resistant to the highly substrate-selective cotransin analogue CT8, was more resistant than wild-type HER3 but only at low coibamide A (3 nM) concentrations; HER3 ... royalty free bluegrassWebCotransin CT8: Breast cancer: Small molecule inhibitor binds the Sec61 translocon and prevents the signal peptide of the nascent HER3 protein from initiating insertion of HER3 into the ER, resulting in HER3 degradation: Ruiz-Saenz et al. (2015) JAK1 and JAK2: Ruxolitinib (INCB018424, INC424) royalty free brand imagesWebSec61 lateral gate, an interaction that is stabilized by cotransin binding (MacKinnon et al., 2014). To test whether apratoxin has a similar stabilizing effect, we prepared ER … royalty free brain iconWebcotransin we screened a large portion of the human secreted proteome (~550 proteins) for sensitivity to CT8 and CT9, potent cotransin analogs. Thus, it is possible to modulate the translocation, and hence functional expression of a subset of secretory proteins, despite utilization of common translocation machinery. royalty free breakcoreWebsubstrate-selective cotransin analogue CT8, was more resistant than wild-type HER3 but only at low coibamide A (3 nM) concentrations; HER3 (G11L/S15L) expression was inhibited by higher concentrations of either natural ... CT8, the CT8-induced loss of HER3 was shown to dramatically suppress HER2-HER3 signaling in HER2-amplified BT474 breast ... royalty free brown noiseWebErin Everett, NP-C, AAHIVS, is a provider of healthcare for transgender patients in Atlanta who offers hormone replacement therapy for both transgender men and women. Erin is … royalty free breastfeeding photos