Glycolysis dc sting
WebThe Journal of Clinical Investigation期刊最新论文，,顶级期刊最新论文图文内容，出版社网站每日同步更新，点击标题直达论文原文，自定义关注的期刊，覆盖PubMed的论文库，快速方便精准的找到您想要的论文 WebApr 27, 2024 · Inflammatory cells switch their metabolism towards glycolysis to meet their high energetic and biosynthetic demand. Interestingly, metabolites that accumulate in glycolytic conditions have been described to reinforce the inflammatory response by modulating intracellular signalling pathways, remodelling the epigenetic landscape or …
Glycolysis dc sting
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WebActivation of STING signaling in DCs promotes antitumor immunity. Aerobic glycolysis is a metabolic hallmark of activated DCs, but how the glycolytic pathway intersects with STING signaling in tumor-infiltrating DCs remains elusive. Here, we show that glycolysis drives STING signaling to facilitate DC-mediated antitumor immune responses. WebJun 1, 2024 · STING and IRF3 are required for spontaneous anti-tumor CD8+ T cell responses and control of tumor growth. Type I IFN production to tumor DNA in DC requires STING, cGAS and IRF3. Empty Cell: IRF3-/-Deng et al. (2014a) IFNAR-/-MC38 + radiation: Type I IFN sensing and STING are required for the anti-tumor effect or radiation.
WebImportantly, glycolysis facilitated STING-dependent DC activity in tissue samples from non-small cell lung cancer patients. Our results provide mechanistic insight into how the crosstalk of glycolytic metabolism and STING signaling enhances DC antitumor activity and can be harnessed to improve cancer therapies. WebJun 1, 2024 · Stimulator of interferon gene (STING) is a crucial regulatory signaling molecule in the DNA-sensing pathway, and its activation can produce strong innate immunity. …
WebImportantly, glycolysis facilitated STING-dependent DC activity in tissue samples from non-small cell lung cancer patients. Our results provide mechanistic insight into how the … WebIn organisms that perform cellular respiration, glycolysis is the first stage of this process. However, glycolysis doesn’t require oxygen, and many anaerobic …
WebMay 14, 2024 · STING is a transmembrane protein that regulates DNA-mediated type I interferon-dependent innate immune responses [ 22 ]. During intracellular bacterial …
ezee taxi motoWeb2 China. Phone: 086-021-22200000-1511; Email: [email protected]. Or to: Xin-Gang Cui, Department of Urology, Xinhua Hospital, Shanghai Jiao Tong University hgua dr balmisWebSep 24, 2024 · The interaction of STAT3 and glycolysis affects STING induction of REG3γ in IECs. Next, we investigated whether STING-induced glycolysis and STAT3 activation affect each other. First, we treated MSIE cells with CMA in the presence or absence of STAT3 inhibitor, HJC0152, for 24 hours, and then measured glycolysis by Seahorse. ezee tile port elizabethWebFeb 23, 2024 · Here, we show that glycolysis drives STING signaling to facilitate DC-mediated antitumor immune responses. Tumor-infiltrating DCs exhibited elevated … hgu84pWebMar 13, 2024 · Glycolysis is the process by which one molecule of glucose is converted into two molecules of pyruvate, two hydrogen ions and two molecules of water. Through this process, the 'high energy' intermediate molecules of ATP and NADH are synthesised. Pyruvate molecules then proceed to the link reaction, where acetyl-coA is produced. … hguaWebJan 11, 2024 · Macrophages rapidly reprogram their metabolic state to facilitate inflammation, resolution, and effector functions [ 4, 5 ]. The metabolic reprogramming of … ezee tileWebSep 8, 2024 · To investigate whether NR works through the cGAS–STING pathway, we depleted cGAS, STING, or used a STING inhibitor in HMC3 microglial cells. Although the SA-β-gal signal was lower after cGAS or STING knockdown, the remaining SA-β-gal staining could not be further reduced by NR treatment in cGAS or STING-deficient cells ( … ezeetax